Rassie Erasmus has named seven uncapped players in his starting 23 to face Wales in Washington on Saturday night.
Ox Nche, Jason Jenkins, Kwagga Smith, Ivan van Zyl Andre Esterhuizen, Makazole Mapimpi and Travis Ismaiel will all get their first run out in the green and gold.
Akker van der Merwe, Thomas du Toit, Marvin Orie, Sikhumbuzo Notshe, Embrose Papier as well as Robert du Preez are all set to earn their first caps off the bench.
Chiliboy Ralepelle makes his comeback as he starts at hooker whilst Elton Jantjies has been charged with controlling a backline that only boasts 53 test caps.
Springbok team to face Wales:
- Ox Nche
- Chilboy Ralepelle
- Wilco Louw
- Jason Jenkins
- Pieter-Steph du Toit (C)
- Kwagga Smith
- Oupa Mahoje
- Dan du Preez
- Ivan van Zyl
- Elton Jantjies
- Makazole Mapimpi
- Andre Esterhuizen
- Jesse Kriel
- Travis Ismaiel
- Curwin Bosch
- Akker van der Merwe
- Steven Kitshoff
- Thomas du Toit
- Marvin Orie
- Sikhumbuzo Notshe
- Embrose Papier
- Robert du Preez
- Warrick Gelant