Rassie Erasmus has picked a fresh front row to take on Argentina as Trevor Nyakane, Beast Mtawarira and Bong Mbonambi all get starting births.
Following the nail-biting draw against the All Blacks, a win should see them claim the Rugby Championship title whilst a bonus point victory would guarantee the trophy.
Faf de Klerk starts again after recovering from a knock with the side otherwise unchanged.
There were lots of question marks over the inside centre position and whether Frans Steyn would get the chance to start but it appears that Erasmus is sticking with what is tried and tested and will likely experiment a bit more in Pretoria next weekend.
Kick-off in Salta is scheduled for 21h40 SAST on Saturday.
Springboks – 15 Willie le Roux, 14 Cheslin Kolbe, 13 Lukhanyo Am, 12 Damian de Allende, 11 Makazole Mapimpi, 10 Handré Pollard, 9 Faf de Klerk, 8 Duane Vermeulen (c), 7 Pieter-Steph du Toit, 6 Kwagga Smith, 5 Franco Mostert, 4 Eben Etzebeth, 3 Trevor Nyakane, 2 Bongi Mbonambi, 1 Tendai Mtawarira.
Subs: 16 Malcolm Marx, 17 Steven Kitshoff, 18 Frans Malherbe, 19 RG Snyman, 20 Francois Louw, 21 Herschel Jantjies, 22 Frans Steyn, 23 Jesse Kriel
