Rassie Erasmus has picked a fresh front row to take on Argentina as Trevor Nyakane, Beast Mtawarira and Bong Mbonambi all get starting births.
A late Herschel Jantjies try converted by Handre Pollard gave South Africa a late 16-16 draw against New Zealand in Christchurch.
Cup holders, New Zealand began their campaign in the Rugby Championship with a narrow 20-16 win over Argentina on Saturday in Buenos Aires.
South Africa ran five tries past the Wallabies in their opening Rugby Championship encounter at Ellis Park in Johannesburg on Saturday evening in a dominant 35-17 victory.
Rugby Championship action begins this weekend, with the opening encounter seeing Springboks host rivals, Wallabies in Johannesburg.
Following their bonus-point win against Australia in the opening fixture of the 2019 Rugby Championship, the Springboks have announced their travelling squad for their clash against New Zealand in Wellington.
Springbok wing and 2018 World breakthrough Player of the Year Aphiwe Dyantyi has been ruled out of the start of the Rugby Championship this weekend after he returned to the Xerox Lions with a hamstring injury.
South Africa Director of Rugby and incumbent Head Coach Rassie Erasmus has targeted a Rugby Championship title as the first goal of the Springbok season ahead of the Rugby World Cup 2019 in Japan.
13 players have been added to the Springboks alignment camp on Friday which includes the likes of Duane Vermeulen, Handre Pollard Lukhanyo Am, Sibusiso Nkosi and Makazole Mapimpi. Francois Louw has also received a call-up.